Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates
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چکیده
منابع مشابه
Potent and Selective Photo-inactivation of Proteins With Peptoid-Ruthenium Conjugates
Advances in high-throughput screening now enable the rapid discovery of bioactive small molecules, but these primary hits almost always exhibit modest potency. We report a strategy for the transformation of these hits into much more potent inhibitors without compound optimization. Appending a derivative of Ru(II)(tris-bipyridyl)(2+), an efficient photosensitizer of singlet oxygen production, to...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2010
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.333